c-MET anticorps (AA 208-407)

N° du produit ABIN3031753

Cet anticorps Lapin Polyclonal détecte spécifiquement c-MET dans WB. Il présente une réactivité envers Humain et Rat.

Aperçu rapide pour c-MET anticorps (AA 208-407) (ABIN3031753)

Antigène: c-MET (MET) (Met Proto-Oncogene (MET))

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp c-MET est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-c-MET anticorps

Épitope: AA 208-407

Purification: Antigen affinity

Immunogène: Human partial recombinant protein (AA 208-407) was used as the immunogen for this c-Met antibody.

Isotype: IgG

Information d'application

Indications d'application: The stated application concentrations are suggested starting points. Titration of the c-Met antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL

Restrictions: For Research Use only

Stockage

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: -20 °C

Stockage commentaire: After reconstitution, the c-Met antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Détails sur c-MET

Antigène: c-MET (MET) (Met Proto-Oncogene (MET))

Autre désignation: C-Met

Sujet: C-Met, also called Hepatocyte growth factor receptor (HGFR), is a protein that in humans is encoded by the MET gene. The protein possesses tyrosine kinase activity. It is a membrane receptor that is essential for embryonic development and wound healing. It induces several biological responses that collectively give rise to a program known as invasive growth. c-Met is deregulated in many types of human malignancies, including cancers of kidney, liver, stomach, breast, and brain. Normally, only stem cells and progenitor cells express the receptor, which allows these cells to grow invasively in order to generate new tissues in an embryo or regenerate damaged tissues in an adult. However, cancer stem cells are thought to hijack the ability of normal stem cells to express c-Met, and thus become the cause of cancer persistence and spread to other sites in the body.

ID gène: 4233

Pathways: Signalisation RTK, Carbohydrate Homeostasis, Synaptic Membrane, Signaling of Hepatocyte Growth Factor Receptor